DeSoto House Hotel

230 South Main Street, Galena, IL 61036

Hotels & Motels

Stay the night at the DeSoto House Hotel on Galena’s Main Street, which dates back to 1855 and is Illinois’ oldest operating hotel, featuring 55 Victorian-style guest rooms, three restaurants and boutiques and enclosed guest parking.

Located in the heart of downtown Galena, DeSoto House Hotel offers a one-of-a-kind stay where rich history and timeless charm come together. Opened in 1855, it is the oldest operating hotel in Illinois and was once known as the “largest hotel in the West,” welcoming travelers during Galena’s booming riverfront era. Today, guests can enjoy beautifully appointed Victorian-style rooms, on-site dining, and an unbeatable location along Main Street—just steps from Galena’s shops, restaurants, and historic attractions. The hotel is also a featured stop on tours by Haunted Galena Tour Co., adding an extra layer of intrigue for those interested in Galena’s storied (and sometimes spooky) past.

History enthusiasts can even stay in the room where Ulysses S. Grant once ran his presidential campaign, making for a truly immersive and memorable experience. As one guest shared, “You can feel the history the moment you walk in, it made our stay in Galena even more special!" - Pete K.