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Main Street Inn

404 S. Main St., Galena, IL 61036

Vacation Rentals

Located on Galena's historic downtown Main Street, the Main Street Inn is a cozy, inviting place to relax that is listed on the National Register of Historic Places (circa 1850).

Main Street Inn offers 6 luxurious and spacious rooms located on the 2nd floor that will meet the needs of romantic adventures, friend getaways, or anything in between. Walk out the front door to take a stroll up Main Street and browse through Galena's unique stores and boutiques, enjoy dining at one of Galena's fine restaurants, or stop by one of our wine shops. Or stay in and simply enjoy the comforts of your room.

Whatever your reason for coming to Galena, the Main Street Inn is here for you!

What's happening nearby...

Galena 45th Annual Halloween Parade

Main Street, Galena •  Oct 25 @ 6:30PM

Join Galena's 45th Annual Halloween Parade & Festival! The largest, longest, and spookiest Parade and Festival in the Tri-State Area!

Read more about Galena 45th Annual Halloween Parade

41st Annual Nouveau Parade & Celebration

Galena Cellars Wine Tasting Room •  Nov 21 @ 11AM

Galena Cellars celebrates the release of the 2025 Nouveau wine - The 41st Annual Celebration!

Read more about 41st Annual Nouveau Parade & Celebration

Galena Holiday Kickoff!

Nov 29 @ 5PM

Join in welcoming Santa to town to kick off the holiday season in Galena!

Read more about Galena Holiday Kickoff!

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